Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Monomers containing 2'-o-alkoxymethyl groups as synthons for the synthesis of oligoribonucleotides by the phosphotriester method].

Bioorganicheskaia khimiia·2012
Same author

[Application of BODIPY-trimethylmelamine conjugate for DNA cross-linking in vitro].

Bioorganicheskaia khimiia·2011
Same author

[Methoxymethyl and (p-nitrobenzyloxy)methyl groups in the synthesis of oligoribonucleotides by the phosphotriester method].

Bioorganicheskaia khimiia·2011
Same author

Cross-linked nucleic acids: isolation, structure, and biological role.

Biochemistry. Biokhimiia·2011
Same author

[DNA mimics on the base of pyrrolidine and hydroxyproline].

Bioorganicheskaia khimiia·2011
Same author

[N-azidomethylbenzoyl blocking group in the phosphotriester synthesis of oligonucleotides].

Bioorganicheskaia khimiia·2010

Related Experiment Video

Updated: Jun 13, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

[Cross-linked nucleic acids: formation, structure, and biological function].

V A Efimov, S V Fediunin, O G Chakhmakhcheva

    Bioorganicheskaia Khimiia
    |April 14, 2010
    PubMed
    Summary
    This summary is machine-generated.

    This review covers covalent cross-linking agents that modify nucleic acids (NA). It details their reactivity, binding, and detection, alongside cellular responses and therapeutic applications.

    More Related Videos

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
    09:32

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

    Published on: April 12, 2019

    Related Experiment Videos

    Last Updated: Jun 13, 2026

    Analyzing and Building Nucleic Acid Structures with 3DNA
    16:24

    Analyzing and Building Nucleic Acid Structures with 3DNA

    Published on: April 26, 2013

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
    09:32

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

    Published on: April 12, 2019

    Area of Science:

    • Molecular Biology
    • Biochemistry
    • Genetics

    Context:

    • Covalent interstrand cross-links are critical modifications to nucleic acids (NA).
    • Understanding these cross-links is vital for various biological processes and therapeutic strategies.
    • Published data on cross-linking reagents and their effects are extensively reviewed.

    Purpose:

    • To summarize the main types of reagents that introduce covalent interstrand cross-links into nucleic acids.
    • To discuss the reactivity and binding sites of these cross-linking agents.
    • To analyze cellular responses to DNA cross-linking and their applications in therapy and molecular biology.

    Summary:

    • The review categorizes reagents that form covalent interstrand cross-links in nucleic acids.
    • It elaborates on the reactivity, target sites, and localization determination of cross-linking agents.
    • Cellular reactions, including blocked replication/transcription, repair initiation, and apoptosis, are analyzed.

    Impact:

    • Provides a comprehensive overview of nucleic acid cross-linking agents.
    • Informs the development of novel therapeutic strategies targeting DNA.
    • Enhances understanding of DNA damage and repair mechanisms in molecular biology.