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Updated: Jun 13, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
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Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

The structure of a gamma-modified peptide nucleic acid duplex

Wei He1, Matthew J Crawford, Srinivas Rapireddy

  • 1Department of Chemistry, Carnegie Mellon University, 4400 5th Avenue, Pittsburgh, PA 15213, USA.

Molecular Biosystems
|April 14, 2010
PubMed
Summary

This study reveals that gamma-methylated peptide nucleic acid (gamma-PNA) duplexes adopt a P-form helical structure with altered base pair rise and helical bending, influenced by the gamma-methyl group.

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