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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
769

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Related Experiment Video

Updated: May 6, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Biomarkers in systemic sclerosis.

Susan V Castro1, Sergio A Jimenez

  • 1Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107-15541, USA. sergio.jimenez@jefferson.edu

Biomarkers in Medicine
|April 14, 2010
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis, an autoimmune disease, needs validated biomarkers for accurate diagnosis and treatment monitoring. Current biomarkers lack thorough validation, highlighting an urgent need for further research in this fibrotic condition.

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Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Background:

  • Systemic sclerosis is an autoimmune inflammatory disorder.
  • It is characterized by microvascular fibroproliferation and immune abnormalities.
  • A severe, progressive fibrotic process is a hallmark of the disease.

Purpose of the Study:

  • To address the unmet need for validated biomarkers in systemic sclerosis.
  • To improve diagnosis, disease classification, and assessment of organ involvement.
  • To facilitate evaluation of therapeutic response in systemic sclerosis patients.

Main Methods:

  • Review of existing literature on systemic sclerosis biomarkers.
  • Analysis of pathogenetic mechanisms including fibroproliferation and immune response.
  • Identification of autoantibodies and other potential biomarkers.

Main Results:

  • Numerous biomarkers reflecting disease mechanisms have been described.
  • Disease-specific autoantibodies are among the few validated markers.
  • Most other biomarkers require further validation.

Conclusions:

  • Validated biomarkers are crucial for systemic sclerosis management.
  • Further research is needed to validate potential diagnostic and prognostic markers.
  • Improved biomarkers will aid in personalized treatment strategies.