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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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[Crohn's disease: genetic aspects].

I D Loranskaia, E V Stepanova

    Terapevticheskii Arkhiv
    |April 15, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Genetic factors significantly influence Crohn's disease (CD). This study examines the NOD2/CARD15 gene's role in CD development and progression in Russia.

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    Area of Science:

    • Gastroenterology
    • Coloproctology
    • Human Genetics

    Context:

    • Crohn's disease (CD) is a significant challenge in modern gastroenterology and coloproctology.
    • Understanding the genetic underpinnings of CD is crucial for effective management.
    • The NOD2/CARD15 gene is a known susceptibility factor for CD.

    Purpose:

    • To investigate the influence of genetic factors on Crohn's disease.
    • To evaluate the effect of major polymorphic variants of the NOD2/CARD15 gene on CD risk and course.
    • To present the first study from Russia on this topic.

    Summary:

    • This paper reviews existing data on genetic factors in Crohn's disease.
    • It presents findings from Russia's first study on the NOD2/CARD15 gene's polymorphic variants.
    • The study assesses the impact of these variants on CD risk, disease progression, and other clinical features.

    Impact:

    • Provides novel insights into the genetic etiology of Crohn's disease in the Russian population.
    • Contributes to the global understanding of NOD2/CARD15 gene's role in CD pathogenesis.
    • May inform future diagnostic and therapeutic strategies for Crohn's disease.