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Related Concept Videos

Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
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Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Solubility03:00

Solubility

Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
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The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

Liposomes remain intact when complexed with polycationic brushes.

Alexander A Yaroslavov1, Andrei V Sybachin, Marc Schrinner

  • 1Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russian Federation. yaroslav@libro.genebee.msu.ru

Journal of the American Chemical Society
|April 15, 2010
PubMed
Summary
This summary is machine-generated.

Anionic liposomes were immobilized on cationic polymer particles. These self-organizing containers retain their properties for potential biomedical applications.

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Area of Science:

  • Materials Science and Nanotechnology
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Liposomes are versatile drug delivery vehicles.
  • Surface modification of polymers is crucial for advanced applications.
  • Controlled immobilization of nanostructures is an active research area.

Purpose of the Study:

  • To investigate the adsorption of anionic liposomes onto cationic polymer particles.
  • To characterize the immobilized liposomes and their properties.
  • To explore the potential of these structures in biomedical fields.

Main Methods:

  • Synthesis of spherical polymer particles with grafted cationic macromolecules.
  • Adsorption of anionic liposomes onto the functionalized polymer surfaces.
  • Characterization of liposome size, shape, and encapsulation efficiency using techniques like dynamic light scattering and microscopy.

Main Results:

  • Anionic liposomes successfully adsorbed onto the cationic polymer particle surfaces.
  • The size and shape of the liposomes remained unchanged after adsorption.
  • Encapsulation ability of the liposomes was preserved upon immobilization.
  • Formation of stable, immobilized self-organizing containers.

Conclusions:

  • The study demonstrates a method for creating immobilized liposomal systems on polymer supports.
  • These immobilized liposomes maintain their structural integrity and functionality.
  • The developed system shows promise for applications in drug delivery and diagnostics.