Related Experiment Video
Updated: Jun 13, 2026

Hydrogen Production and Utilization in a Membrane Reactor
Published on: March 10, 2023
A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical
Masaaki Nakayama1, Hirofumi Nakano, Hiromi Hamada
1Tohoku University Hospital, Department of Blood Purification, Sendai, Japan. mnakayama@mail.tains.tohoku.ac.jp
Background:
Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects.
Methods:
Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.
Results:
During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified.
Conclusions:
Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.
Related Concept Videos
Hemodialysis I: Introduction
Hemodialysis II: Procedure and Complications
Dialysis
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Hemodialysis III: Nursing Management
