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Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jun 13, 2026

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes

Published on: November 11, 2016

Stem cells as vectors for antitumour therapy.

Michael R Loebinger¹, Sam M Janes

¹Centre For Respiratory Research, Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK.

|April 15, 2010

Summary

Mesenchymal stem cells (MSCs) show promise for targeted cancer therapy by migrating to tumors. This review explores MSC-based anticancer agents, addressing safety concerns and future applications in cancer management.

Area of Science:

Oncology
Stem Cell Biology
Cancer Therapy

Background:

Mesenchymal stem cells (MSCs) exhibit inherent tumor-homing capabilities.
MSCs can be engineered to deliver therapeutic payloads, offering targeted cancer treatment potential.
Concerns exist regarding systemic delivery of MSCs and the precise mechanisms of tumor homing.

Purpose of the Study:

To review various anticancer agents delivered by MSCs.
To address safety concerns and unanswered questions surrounding MSC-based cancer therapy.
To evaluate the future role of MSCs in cancer management.

Main Methods:

Literature review of studies on MSC-delivered anticancer agents.
Analysis of research addressing MSC tumor homing mechanisms.

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Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells

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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Discussion of potential benefits and risks of MSC-based cancer therapies.

Main Results:

Several types of MSC-delivered anticancer agents have been investigated.
The exact mechanisms of MSC tumor homing require further elucidation.
Potential for MSCs as targeted delivery vehicles for cancer treatment is significant but requires careful consideration of safety.

Conclusions:

MSCs hold promise as targeted anticancer agents.
Further research is needed to optimize MSC delivery and address safety concerns.
MSC-based therapies could become a valuable component of future cancer management strategies.