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Capsaicin pretreatment does not inhibit allergen-induced airway microvascular leakage in guinea pig
J O Lötvall1, K P Hui, C G Löfdahl
1Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Allergy
|February 1, 1991
Abstract:
We have studied the effects of tachykinin-depletion on airway microvascular leakage induced by allergen challenge in ovalbumin-sensitised guinea pigs. Tachykinin-depletion was obtained by capsaicin pretreatment 1 week before inhaled allergen challenge. Capsaicin pretreatment did not change airway microvascular permeability induced by allergen challenge. Thus, sensory neuropeptides may not be important in allergen-induced acute airway microvascular leakage in guinea pig in vivo.