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Related Experiment Videos

Cocaine-associated chest pain.

J L Zimmerman1, R P Dellinger, P A Majid

  • 1Department of Medicine, Baylor College of Medicine, Houston, Texas.

Annals of Emergency Medicine
|June 1, 1991
PubMed
Summary
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Cocaine abusers presenting with chest pain show significant electrocardiogram (ECG) abnormalities, with a notable incidence of myocardial infarction. Chronic cocaine use may lead to lasting heart changes causing ischemia.

Area of Science:

  • Cardiology
  • Toxicology
  • Emergency Medicine

Background:

  • Cocaine abuse is associated with cardiovascular complications, including chest pain.
  • Patients presenting with chest pain require prompt evaluation for potential myocardial infarction.

Purpose of the Study:

  • To characterize the clinical and electrocardiogram (ECG) features of cocaine abusers with chest pain.
  • To assess the incidence of myocardial infarction in this population.

Main Methods:

  • Retrospective review of 48 adult cocaine abusers admitted with chest pain.
  • Analysis of presenting symptoms, duration of cocaine abuse, and ECG findings.

Main Results:

  • Chest pain occurred variably in relation to cocaine use.

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  • Significant ECG abnormalities, including ST segment elevations and T-wave inversions, were common.
  • Three patients (6.25%) were diagnosed with acute myocardial infarction.

    • Conclusions:

    • A small but significant incidence of myocardial infarction exists in cocaine abusers with chest pain.
    • Persistent ECG abnormalities and variable timing of chest pain suggest chronic myocardial changes from cocaine abuse.