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Related Concept Videos

Birth Control Methods01:22

Birth Control Methods

Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...

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Related Experiment Video

Updated: Jun 13, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Recent innovations in oral contraception.

Miriam Cremer1, Scarlett Phan-Weston, Adam Jacobs

  • 1Department of OB/GYN, The Mount Sinai Medical Center, New York, NY 10029-6574, USA. mlcremer@hotmail.com

Seminars in Reproductive Medicine
|April 15, 2010
PubMed
Summary

Extended oral contraception regimens offer comparable safety and efficacy to traditional methods, with improved patient satisfaction and reduced menstrual side effects. New formulations, including those with drospirenone, are available.

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Area of Science:

  • Reproductive Medicine
  • Pharmacology

Background:

  • Traditional oral contraception involves 21 days of hormones followed by a 7-day hormone-free interval (HFI).
  • Extended regimens (e.g., 24/4, 84/7, 365-day) have been approved since 2003 to shorten the HFI.

Purpose of the Study:

  • To review new oral contraceptive formulations available in the United States.
  • To summarize current literature on drospirenone-containing oral contraceptives.

Main Methods:

  • Literature review of extended oral contraceptive regimens.
  • Review of studies on drospirenone's properties and efficacy.

Main Results:

  • Extended regimens demonstrate safety and efficacy comparable to traditional 21/7 dosing.
  • These regimens are associated with high patient satisfaction, shorter or similar bleeding patterns, and improved menstrual symptoms.
  • Drospirenone, a component in some new formulations, possesses antimineralocorticoid and antiandrogenic properties.

Conclusions:

  • Extended oral contraceptive regimens offer a favorable alternative to traditional dosing with comparable safety and efficacy.
  • New formulations, particularly those containing drospirenone, provide benefits such as improved patient satisfaction and symptom management.