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Updated: Jun 13, 2026
Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Primary cutaneous ewing's sarcoma/primitive neuroectodermal tumor: report of the first case diagnosed on aspiration
Sonali Kalra1, Ruchika Gupta, Sompal Singh
1Department of Pathology, Hindu Rao Hospital, Malka Ganj, Delhi, India.
Background:
Extraskeletal Ewing's sarcoma (ES) was first recognized as a soft tissue tumor in 1975. Primacy cutaneous occurrence of Ewing's sarcoma/primitive neuroectodermnal tumor (ES/PNET) has been reported in only 31 cases so far. To the best of our knowledge, there is no report of preoperative cytologic diagnosis of cutaneous ES/PNET in the available literature except for this one.
Case:
A young adult presented with a recurrent swelling on the medial aspect of the left leg that had been present for the past 5 years. Fine needle aspiration cytology yielded cellular smears showing a small round cell tumor. Immunostaining on cell block material showed positivity for CD99, S-100 protein and neuron-specific enolase. A cytologic diagnosis of primary cutaneous ES/PNET was made. Local excision was performed, and the patient was well after 2 years of follow-up.
Conclusion:
Primary cutaneous ES/PNET is a rare cutaneous tumor with a favorable clinical outcome. It can be diagnosed on cytology; however, immunocytochemistry is mandatory for differentiation from other small round cell tumors.
