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Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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Related Experiment Video

Updated: Jun 13, 2026

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

Yeast chromosomal interactions and nuclear architecture.

Justin M O'Sullivan1

  • 1Institute of Natural Sciences, Massey University, Auckland, New Zealand. j.m.osullivan@massey.ac.nz

Current Opinion in Cell Biology
|April 16, 2010
PubMed
Summary

This review explores chromosomal interactions, revealing how they form networks within the genome. Understanding these interactions is key to studying genome biology as an interconnected system, not just isolated DNA segments.

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Last Updated: Jun 13, 2026

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae
07:48

Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

Published on: October 11, 2022

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12:06

Surface Spreading and Immunostaining of Yeast Chromosomes

Published on: August 9, 2015

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
12:04

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

Area of Science:

  • Genomics
  • Molecular Biology
  • Cell Biology

Background:

  • Biology fundamentally studies interaction networks within and between organisms.
  • Genome biology traditionally viewed genes as isolated loci.
  • Emerging research links chromosomal interactions, nuclear positioning, and genomic function.

Purpose of the Study:

  • To outline the mechanisms determining chromosomal interactions.
  • To review recent findings on intra- and inter-chromosomal interactions in yeast.
  • To present a model for yeast chromosomal interaction formation and nuclear structure.

Main Methods:

  • Literature review of recent studies on chromosomal interactions.
  • Analysis of intra-chromosomal and inter-chromosomal interactions in yeast.
  • Examination of interactions involving foreign DNA.

Main Results:

  • Chromosomal interactions are intricately linked with nuclear position and genome function.
  • Yeast studies reveal diverse intra- and inter-chromosomal interaction patterns.
  • Foreign DNA can integrate into and influence chromosomal interactions.

Conclusions:

  • A model is proposed to explain the formation of chromosomal interactions in yeast.
  • This model elucidates the establishment of yeast interphase nuclear architecture.
  • Understanding chromosomal interactions is crucial for a network-based view of genome biology.