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Related Experiment Video

Updated: Jun 13, 2026

Ferric Chloride-induced Murine Thrombosis Models

Ferric Chloride-induced Murine Thrombosis Models

Published on: September 5, 2016

Tissue factor and thrombosis models.

Colin A Kretz¹, Nima Vaezzadeh, Peter L Gross

¹Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

Arteriosclerosis, Thrombosis, and Vascular Biology

|April 16, 2010

Summary

This summary is machine-generated.

Investigating tissue factor (TF) in thrombosis using mouse models is crucial. This review explores TF

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

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Extracellular Vesicle Tissue Factor Activity Assay

Extracellular Vesicle Tissue Factor Activity Assay

Published on: December 29, 2023

Area of Science:

Hemostasis and Thrombosis Research
Vascular Biology
Genetic Mouse Models

Background:

Tissue factor (TF) plays a critical role in thrombogenesis.
TF deficiency is embryonic lethal in mice, necessitating advanced genetic models.
TF expression varies across cell types, with controversial roles in platelets and endothelial cells.

Purpose of the Study:

To review data from mouse models investigating TF's role in thrombus formation.
To delineate the contribution of TF from specific cell types to thrombosis.
To develop unifying concepts for future research on TF in vascular injury.

Main Methods:

Analysis of existing literature on mouse models of thrombosis.
Evaluation of studies using various vascular injury techniques.
Consolidation of data to identify model-dependent TF sources.

Main Results:

Mouse models are essential for studying TF in thrombosis.
TF's contribution to thrombus formation is model-dependent.
Rigorous controls are needed to attribute thrombosis to specific TF sources.

Conclusions:

Understanding TF's cell-specific roles in thrombosis requires sophisticated mouse models.
Future studies should focus on testing unifying concepts derived from model-dependent data.
Further research is needed to clarify TF's precise contribution to thrombogenesis in different vascular injury contexts.