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Updated: Jun 13, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Reversal of adrenal suppression with ciclesonide
Mariel Kupfert Heller1, Jessica Laks, Thomas Andrew Kovesi
1Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Background:
Adrenal suppression secondary to high-dose inhaled corticosteroid use has been reported in children.
Methods:
The authors report the use of ciclesonide to reverse adrenal suppression secondary to inhaled fluticasone use in four pediatric patients.
Results:
In these four children, hypothalamic-pituitary-adrenal axis function normalized after the patients were changed to ciclesonide, while good asthma control was maintained.
Conclusions:
Ciclesonide should be considered for the reversal of adrenal suppression secondary to the use of fluticasone, and perhaps other older inhaled corticosteroids as well.
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