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Predisposing factors for acute otitis media in infancy
Fani Ladomenou1, Anthony Kafatos, Yiannis Tselentis
1Department of Paediatrics, University of Crete, Heraklion 71003, Greece.
Insights
Infant acute otitis media (AOM) risk factors include siblings, daycare, maternal illness, and poor breastfeeding. These findings highlight modifiable factors for AOM prevention in infants.
Area of Science:
- Pediatrics
- Epidemiology
- Public Health
Background:
- Acute otitis media (AOM) is a common childhood illness with incompletely understood predisposing factors.
- Identifying risk factors is crucial for developing effective prevention strategies.
Purpose of the Study:
- To prospectively investigate the incidence rates and risk factors associated with AOM in a systematic sample of infants.
- To analyze the relationship between various infant, family, and environmental factors and AOM occurrence.
Main Methods:
- A cohort of 1049 mother-infant pairs was followed for 12 months post-birth.
- Data on AOM episodes were collected via parental reports of physician diagnoses.
- Multivariate analysis was used to assess 21 potential risk factors.
Main Results:
- 28.6% of infants experienced at least one AOM episode; 6.16% had multiple episodes.
- Key risk factors identified included: presence of siblings, out-of-home daycare, maternal ill health during pregnancy, suboptimal breastfeeding, and lower parental education.
- Hospitalization for AOM was associated with younger maternal age.
Conclusions:
- Infant AOM presents significant morbidity, influenced by several identifiable infant and family-related factors.
- The study identifies several factors that may be amenable to intervention for AOM prevention.
Summary Background:
Factors predisposing to acute otitis media (AOM) are not thoroughly understood.
Objectives:
In this study we prospectively investigated incidence rates and risk factors of AOM in a systematic sample of infants in a well-defined population.
Design And Subjects:
Following interview soon after delivery in a representative sample of 1049 mother-infant pairs, information was collected 1, 3, 6, 9 and 12 months after birth. Episodes of AOM were recorded as by parental reports of diagnosis made by a physician. AOM frequency was further analyzed against 21 social, maternal, paternal, prenatal, perinatal and infantile factors.
Results:
Successful 12-month follow-up was achieved for 926/1049 infants (88.3%), of whom 265 (28.6%) were reported with episodes of AOM; 153 with a single, 55 with two, and 57 with three to six episodes (16.5%, 5.94%, and 6.16% respectively). Factors founded by multivariate analysis to predispose to AOM included presence of siblings (P<0.001), out-of-home daycare (P<0.001), ill health in pregnancy (P<0.01), and suboptimal breastfeeding (P<0.01). Multiple (3 or more) episodes were related to presence of siblings (P<0.0001), out-of-home daycare (P<0.001), ill health in pregnancy (P<0.001), and low parental education (P<0.001). 28 infants were hospitalized (10.6% of infants with AOM, 3.02% of the total cohort). Hospitalization was related to young maternal age (P<0.05).
Conclusions:
Our findings confirm the high morbidity of AOM during infancy and point to several infant- and family-related predisposing factors, some of which are liable to intervention.
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