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Updated: Jun 13, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Early determination of toxicant concentration in water supply using MHE
1Department of Chemical and Material Engineering, University of Alberta, Canada T6G 2G6. fadi.ibrahim@ualberta.ca <fadi.ibrahim@ualberta.ca>
Abstract:
In this paper, a novel application of state estimation in environmental engineering is presented. The objective is to use on-line estimation techniques including moving horizon estimator (MHE) and extended Kalman filer (EKF) for an early concentration estimation of toxic agent presented in water supply. These estimation techniques (MHE and EKF) can be integrated in an early warning system of several features including the ability of early detection and quantification of the presence of toxicants in the water supply system. The estimation is based on dynamic measurements generated by a real-time cell electronic sensor (RT-CES) and on existing cytotoxicity mathematical dynamic models.
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