Related Experiment Video
Updated: Jun 13, 2026

Evaluation of Substrate Ubiquitylation by E3 Ubiquitin-ligase in Mammalian Cell Lysates
Published on: May 10, 2022
[Relationship of ubiquitin-ligases APC/C and SCF complex to cancer]
Shu-jing Li1, Hai-lian Bi, Hui-jian Wu
1School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China.
Abstract:
Ubiquitin ligases are an important component in ubiquitination system, which can recognize substrate proteins specially to promote their degradation. Closely related to the generation and development of many tumors, ubiquitin ligases can regulate the growth, differentiation and apoptosis of cells by influencing protein stability, which makes them a potential new target for tumor molecular therapy. There are many kinds of ubiquitin ligases, mainly including APC/C and SCF complex. This article will introduce the structures and functions of these two kinds of ubiquitin ligases and their roles in the tumor generation and development.
Related Concept Videos
Anaphase Promoting Complex
Anaphase Promoting Complex
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Separation of Sister Chromatids
At the onset of anaphase, separase, a proteolytic enzyme, is...
Regulated Protein Degradation
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
The Intrinsic Apoptotic Pathway

