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High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster
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Genotyping sleep disorders patients.

Daniel F Kripke1, Farhad F Shadan, Arthur Dawson

  • 1Scripps Clinic Sleep Center, La Jolla, California, USA.

Psychiatry Investigation
|April 17, 2010
PubMed
Summary
This summary is machine-generated.

Genetic factors for sleep disorders are being investigated. While some associations were found, specific single nucleotide polymorphisms (SNPs) are not yet clinically useful for diagnosing sleep disorders.

Keywords:
APOEDepressionGenotypeSleepSleep apneaTEF

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Area of Science:

  • Genetics
  • Sleep Medicine
  • Clinical Research

Background:

  • Genetic susceptibility factors for sleep disorders could inform prognosis and treatment.
  • Replication and validation of candidate polymorphisms for clinical utility are currently insufficient.

Purpose of the Study:

  • To assess the clinical validity of candidate genetic associations for various sleep disorders.
  • To investigate the relationship between specific single nucleotide polymorphisms (SNPs) and sleep disorder phenotypes.

Main Methods:

  • Collected saliva DNA and clinical data from 360 participants undergoing polysomnography.
  • Genotyped ten single nucleotide polymorphisms (SNPs) associated with depression, circadian rhythm, sleep apnea, restless legs syndrome (RLS), excessive sleepiness, and slow wave sleep.

Main Results:

  • Confirmed association between TEF rs738499 and depressive symptoms.
  • Found equivocal evidence for rs1801260 (CLOCK gene) and morningness/eveningness, and for Apolipoprotein E (APOE) rs429358 with excessive sleepiness (Epworth Sleepiness Scale).
  • Did not confirm predicted associations between SNPs and sleep apnea, RLS, or slow wave sleep.

Conclusions:

  • The single nucleotide polymorphisms (SNPs) evaluated do not, on their own, have clinical utility for genotyping in sleep clinics.
  • Further research is needed to identify reliable genetic markers for sleep disorder prediction and treatment.