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Published on: November 4, 2021
Embolic infarction associated with cardiac amyloidosis
Kyung-Hee Cho1, Yong Mee Cho, Jong S Kim
1Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Journal of Clinical Neurology (Seoul, Korea)
|April 17, 2010
Summary
Cardiac amyloidosis, a rare condition, can cause embolic cerebral infarction. This study highlights how heart involvement in amyloidosis leads to stroke, emphasizing the need for recognition of this serious complication.
Area of Science:
- Cardiology
- Neurology
- Pathology
Background:
- Embolic cerebral infarction is a serious neurological event.
- Cardiac amyloidosis is a rare infiltrative cardiomyopathy.
- The link between cardiac amyloidosis and cerebral infarction is not well-established.
Purpose of the Study:
- To report cases of embolic cerebral infarction in patients with cardiac amyloidosis.
- To investigate the mechanism linking cardiac amyloidosis to stroke.
- To raise awareness of cardiac amyloidosis as a cause of cardioembolic infarction.
Main Methods:
- Case report of two patients with confirmed amyloidosis.
- Myocardial biopsy for Patient 1 to confirm cardiac amyloidosis.
- Kidney biopsy and echocardiography for Patient 2, revealing characteristic features of cardiac amyloidosis.
Main Results:
- Both patients presented with embolic cerebral infarcts.
- Patient 1: Myocardial biopsy confirmed amyloidosis.
- Patient 2: Kidney biopsy and echocardiography showed granular sparkling, restrictive cardiomyopathy, and mural thrombus, indicative of cardiac amyloidosis.
Conclusions:
- Cardiac amyloidosis can lead to impaired myocardial function and mural thrombosis.
- Mural thrombosis in the heart can result in embolic cerebral infarction.
- Cardiac amyloidosis should be considered a potential cause of cardioembolic stroke.
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