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Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats
Published on: January 31, 2019
Experimental study of hypotensive effect of kardos in rats with inherited hypertension
N A Medvedeva1, M M Artem'eva, I A Kheyfets
1Biological Faculty, M V Lomonosov Moscow State University.
Bulletin of Experimental Biology and Medicine
|April 17, 2010
Abstract:
Kardos, a preparation containing ultralow doses of antibodies to C-terminal fragment of type 1 receptor of angiotensin II, intragastrically administered to SHR rats with hereditary hypertension for 28 days reduced blood pressure by 14.8%. Kardos was not inferior to losartan and, in contrast to the latter reduced HR by 9.4%.
