Naloxone effects on behavior of inbred mice with different response to emotional stress in open field test
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Updated: Jun 13, 2026
Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
Published on: February 6, 2015
A V Nadorova1, M M Kozlovskaja, S B Seredenin
1Department of Pharmacogenetics V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. av-nadorova@mail.ru
Abstract:
Effects of nonspecific opiate receptor antagonist naloxone in doses of 0.1, 0.5, 1.0, 5.0, 10.0 mg/kg on open field behavior and spontaneous motor activity were studied in male BALB/c and C57Bl/6 mice. Differently directed effects of naloxone on behavioral parameters of emotional-stress reaction in BALB/c and C57Bl/6 mice were observed. Naloxone increased motor activity in the open field test in BALB/c mice, but decreased it in C57Bl/6 mice. In the absence of stress, naloxone in the studied dose range did not affect spontaneous motor activity in C57Bl/6 mice, and significantly reduced activity in BALB/c mice in doses 0.5 and 1.0 mg/kg.
