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Updated: Jun 13, 2026
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
Published on: January 25, 2019
Methodological guidelines for genetic safety testing of cell transplants
N P Bochkov1, V A Nikitina, E S Voronina
1Laboratory of Mutagenesis, Medical Genetic Center, Russian Academy of Medical Sciences, Russia.
Bulletin of Experimental Biology and Medicine
|April 17, 2010
Abstract:
A combination of karyotyping and aneuploidy analysis by interphase fluorescent in situ hybridization is a sensitive method for evaluation of genetic stability of stem cell cultures. The methodology and specific features of preparing and analyzing the cytogenetic preparations are described as exemplified by human multipotent mesenchymal stromal cells.
