Modeling of chronic herpesvirus infection. Experimental studies of infectious process in mice

The dynamics of infectious process was studied by modeling chronic herpesvirus infection in mice. The infectious process ran a wave-like course with periods of relapses and remissions. Clinical manifestations and severity and duration of relapses largely depended on the disease duration. Reactivation of herpesvirus led to systemic involvement, this indicating the dissemination of infection in animals and chronic transformation of the disease.