Related Experiment Video

Updated: Dec 25, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.7K

Patient-based strategy for systemic treatment of metastatic renal cell carcinoma

Hartmut Kirchner1, Dirk Strumberg, Amit Bahl

  • 1Klinikum Region Hannover GmbH, Krankenhaus Siloah, Medizinische Klinik III, Roesebeckstr 15, 30449 Hannover, Germany. hartmut.kirchner@krh.eu

Expert Review of Anticancer Therapy
|April 20, 2010
PubMed

Insights

Targeted therapies have transformed metastatic renal cell carcinoma (mRCC) treatment, offering new options. This review proposes a patient-based algorithm considering tumor burden, disease pace, and quality of life for optimal mRCC care.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Metastatic renal cell carcinoma (mRCC) historically had a poor prognosis with limited treatment options.
  • The landscape of mRCC treatment has significantly improved since December 2005 with the advent of targeted therapies.

Purpose of the Study:

  • To review available targeted therapies for mRCC.
  • To evaluate patient-specific criteria for therapy selection.
  • To propose an algorithm for a patient-based treatment scheme in mRCC.

Main Methods:

  • Selective literature search focusing on six targeted therapies for mRCC.
  • Inclusion of data from recent American Society of Clinical Oncology (ASCO) and European Society for Medical Oncology (ESMO) Annual Meetings.
  • Evaluation of clinical experiences with sequential and potential combination therapies.

Main Results:

  • Several promising targeted therapies are now available for mRCC, improving patient longevity and quality of life.
  • No universally accepted treatment scheme for targeted therapies in mRCC currently exists.
  • A proposed algorithm prioritizes tumor burden, disease pace, and patient quality of life to guide treatment decisions.

Conclusions:

  • The proposed treatment scheme for mRCC is based on crucial patient-specific criteria: tumor burden, disease pace, and quality of life.
  • These criteria determine whether the primary therapeutic goal should be tumor control or tumor remission.
  • The algorithm provides guidance on therapeutic sequencing to optimize patient care in mRCC.

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

14.0K
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

34.0K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
275
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
141
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K