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Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis
Huiying Wang1, Dandan Wu, Hua Xiang
1Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University Medical School, Respiratory Institute of Zhejiang University, 88 Jiefang Road, 310009 Hangzhou, Zhejiang Province, People's Republic of China. w_huiying@yahoo.com
Abstract:
Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin's lymphoma (NHL) developed after 11 years' methotrexate therapy for RA. Biopsy of the pulmonary mass demonstrated a diffuse large B-cell lymphoma. After withdrawal of methotrexate without any other intervention for 4 weeks, a significant reduction in the size of the lymphoma was observed. The causative relationship between methotrexate and pulmonary lymphoma is suggested by the persistent remission after stopping methotrexate therapy.
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