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Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Related Experiment Video

Updated: Jun 13, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

Patients under anti-platelet therapy.

Pierre Albaladejo1, Charles Marc Samama

  • 1Department of Anaesthesiology and Intensive Care, Grenoble University Hospital, Grenoble CEDEX 9, France.

Best Practice & Research. Clinical Anaesthesiology
|April 21, 2010
PubMed
Summary

Managing anti-platelet agents (APAs) during surgery requires balancing cardiovascular and bleeding risks. This review details APA use, interruption strategies, and resumption timing for clinical practice.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Practice

Background:

  • Anti-platelet agents (APAs) are crucial for preventing thrombotic events, particularly after stent implantation.
  • Interruption or continuation of APAs during surgical or invasive procedures presents a dilemma, balancing risks of thrombosis versus bleeding.

Purpose of the Study:

  • To review the pharmacology and indications of common APAs (aspirin, clopidogrel, prasugrel).
  • To detail the risks and benefits of APA interruption and resumption around surgical procedures.
  • To provide guidance on optimal timing for APA interruption and resumption, including bridging strategies.

Main Methods:

  • Literature review of anti-platelet agent pharmacology and clinical guidelines.
  • Analysis of risks associated with APA interruption and maintenance during invasive procedures.

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

  • Synthesis of evidence regarding optimal peri-procedural APA management.

    • Main Results:

    • Interruption of APAs increases cardiovascular complication risk.
    • Maintenance of APAs increases haemorrhagic complication risk.
    • Optimal timing for interruption and resumption depends on the specific APA and procedure.

    Conclusions:

    • Careful consideration of APA management is essential to minimize peri-procedural complications.
    • Bridging strategies may be considered in select high-risk patients.
    • Evidence-based and non-evidence-based suggestions are provided to aid clinical decision-making.