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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

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Related Experiment Video

Updated: Jun 13, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Hypercoagulability in the perioperative period.

Vance G Nielsen1, Lars M Asmis

  • 1Drexel University College of Medicine, Department of Anesthesiology, Philadelphia, Pennsylvania 19102, USA. vance.nielsen@drexelmed.edu

Best Practice & Research. Clinical Anaesthesiology
|April 21, 2010
PubMed
Summary

Postoperative thrombotic complications like deep venous thrombosis and pulmonary embolism increase hospital stays and mortality. This review identifies at-risk patients and procedures, diagnostic methods, and therapeutic strategies to minimize these risks.

Related Experiment Videos

Last Updated: Jun 13, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
04:56

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)

Published on: August 4, 2023

Area of Science:

  • Medical Sciences
  • Surgical Complications
  • Hematology

Background:

  • Thrombotic and thrombo-embolic events are significant postoperative complications.
  • These events contribute to perioperative morbidity and mortality, increasing hospital stays.

Purpose of the Study:

  • To identify procedures and patient groups at risk for postoperative thrombophilia.
  • To link hematological/biochemical changes to thrombotic complications.
  • To review diagnostic modalities and therapeutic strategies for minimizing postoperative thrombosis.

Main Methods:

  • Literature review of studies on postoperative thrombotic complications.
  • Analysis of hematological and biochemical markers associated with thrombosis.
  • Evaluation of diagnostic tools for detecting thrombosis.
  • Assessment of therapeutic interventions for prevention and treatment.

Main Results:

  • Certain surgical procedures and patient populations exhibit higher thrombophilia risk.
  • Specific hematological and biochemical alterations are implicated in postoperative thrombosis.
  • Various diagnostic methods aid in identifying thrombotic events.
  • Rational therapeutic approaches can mitigate thrombotic risks.

Conclusions:

  • Understanding risk factors and implementing appropriate diagnostic and therapeutic strategies are crucial.
  • Minimizing postoperative thrombotic complications requires a comprehensive approach.
  • Further research into predictive markers and targeted therapies is warranted.