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Hypercalciuria in Jahrom's school-age children: what is normal calcium-creatinine ratio?

Fatemeh Emamghorashi1, Mohammad Hassan Davami, Reyhaneh Rohi

  • 1Jahrom University of Medical Sciences, Jahrom and Shiraz Nephro-Urology Research Center, Shiraz, Iran. ghoraishy@yahoo.com

Iranian Journal of Kidney Diseases
|April 21, 2010
PubMed

Insights

This study established normal urine calcium-creatinine (Ca/C) ratios for Iranian children in Jahrom. A 95th percentile Ca/C ratio of 0.25 was identified, with 5.1% of children showing hypercalciuria.

Area of Science:

  • Pediatric Nephrology
  • Clinical Biochemistry
  • Public Health

Background:

  • Establishing normative data for urinary calcium-creatinine (Ca/C) ratio is crucial for diagnosing pediatric kidney disorders.
  • Previous studies have not specifically addressed reference values for Iranian children in the Jahrom region.

Purpose of the Study:

  • To determine normal reference values for the urine calcium-creatinine (Ca/C) ratio in school-aged children residing in Jahrom, Iran.
  • To identify the prevalence of hypercalciuria within this pediatric population.

Main Methods:

  • A stratified clustered random sampling method was employed to recruit 1068 school-aged children from Jahrom primary schools.
  • Nonfasting random urine samples were collected and analyzed for calcium and creatinine concentrations between March and May 2008.

Main Results:

  • The overall mean urine Ca/C ratio was 0.123 ± 0.106, with a 95th percentile value of 0.25.
  • No significant gender-based differences were observed in nonfasting Ca/C ratios.
  • The highest mean Ca/C ratio was found in 9-year-old children (0.132 ± 0.11), where hypercalciuria prevalence was also highest (9.3%).

Conclusions:

  • Reference values for urine Ca/C ratio in southeastern Iranian children were established.
  • Age and ethnicity are important factors to consider when interpreting urinary solute-creatinine ratios in pediatric populations.
Abstract

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