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Liver transplantation for hepatocellular carcinoma
1Department of Surgery, LifeLink HealthCare Institute, Tampa, FL 33606, USA. angel.alsina@lifelinkfound.org
Cancer Control : Journal of the Moffitt Cancer Center
|April 21, 2010
Summary
Liver transplantation is a viable treatment for unresectable hepatocellular carcinoma (HCC). Evolving eligibility criteria, including the Milan criteria and the "rule of 7," improve patient selection for this life-saving procedure.
Area of Science:
- Hepatobiliary surgery
- Transplant surgery
- Oncology
Background:
- Hepatocellular carcinoma (HCC) presents significant treatment challenges.
- Liver transplantation is an established therapeutic option for select HCC patients.
Purpose of the Study:
- To review evolving eligibility criteria for liver transplantation in HCC.
- To evaluate institutional outcomes of liver transplantation for HCC.
- To describe a method for HCC prognosis assessment.
Main Methods:
- Review of current and expanded eligibility criteria for liver transplantation in HCC.
- Analysis of institutional treatment outcomes for liver transplantation in HCC patients.
- Description of a prognostic evaluation method.
Main Results:
- Eligibility is determined by the Milan criteria or expanded UCSF criteria (e.g., "rule of 7").
- A preliminary institutional review of 91 HCC patients who underwent liver transplantation (1996-2008) showed an 11% tumor recurrence rate.
Conclusions:
- Liver transplantation provides a chance for long-term survival in HCC patients with unresectable tumors and chronic cirrhosis.
- Patient selection criteria for liver transplantation in HCC are continuously refined.
