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Small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia: a case report and literature review
Esther S Ng1, Kotamma Venkateswaran, Shridhar I Ganpathi
1Department of Medicine, National University Health System, Singapore, Singapore.
Introduction:
Gallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis.
Case Report:
We report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy.
Discussion:
There have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma.
Conclusion:
Symptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome.
