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Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune responses to T-independent and

A Quintanar-Stephano1, E Abarca-Rojano, R A Jarillo-Luna

  • 1Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México.

Journal of Physiology and Biochemistry
|April 22, 2010
PubMed
Summary

Hypophysectomy (HYPOX) and neurointermediate pituitary lobectomy (NIL) impact rat immune responses. Hormones from both the anterior and posterior pituitary regulate humoral immunity, affecting responses to various antigens.

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Area of Science:

  • Immunology
  • Endocrinology
  • Physiology

Background:

  • The pituitary gland, comprising anterior and posterior lobes, produces hormones crucial for numerous bodily functions.
  • Previous studies indicate that hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) in rats can diminish both humoral and cell-mediated immune responses.
  • The distinct roles of anterior versus posterior pituitary hormones in modulating immune function remain largely uncharacterized.

Purpose of the Study:

  • To investigate and compare the specific effects of anterior and posterior pituitary hormones on humoral immune responses in rats.
  • To elucidate the differential impact of HYPOX and NIL on immune reactions to T cell-independent (TI) and T cell-dependent (TD) antigens.

Main Methods:

  • Rats underwent sham surgery (SHAM), HYPOX, or NIL procedures.
  • Humoral immune responses were assessed using T cell-independent antigens (DNP-LPS for TI-1, DNP-FICOLL for TI-2) and T cell-dependent antigens (ovalbumin [OVA] and bovine serum albumin [BSA]).
  • Immunoglobulin M (IgM) and immunoglobulin G (IgG) responses were quantified and compared across experimental groups.

Main Results:

  • Both HYPOX and NIL significantly reduced IgM responses to TI-1 antigens.
  • NIL, but not HYPOX, led to a decreased IgM response against TI-2 antigens.
  • Both HYPOX and NIL similarly decreased IgG responses to TI-2 antigens.
  • IgM responses to TD antigens remained unchanged post-HYPOX or NIL, while IgG responses to OVA and BSA were significantly reduced.

Conclusions:

  • Hormones originating from the anterior and posterior pituitary lobes exert distinct regulatory roles in humoral immune responses.
  • These findings highlight the specific contributions of different pituitary hormone subsets to the maintenance of immune system integrity.