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Updated: Feb 20, 2026

Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Evaluation of infants and children with refractory lower respiratory tract symptoms
1Capital Allergy and Respiratory Center, Sacramento, California 95819, USA. bchipps@capitalallergy.com
Insights
Recurrent wheezing in young children often leads to an asthma diagnosis. If asthma treatment fails, consider other conditions like reflux or cystic fibrosis for accurate diagnosis and management.
Area of Science:
- Pediatric Pulmonology
- Diagnostic Medicine
Background:
- Recurrent wheezing is a common presentation in young children.
- Asthma is frequently diagnosed, but treatment is not always effective.
Purpose of the Study:
- To outline diagnostic considerations for recurrent wheezing in children.
- To identify differential diagnoses when asthma therapy is unsuccessful.
Main Methods:
- Literature review.
- Analysis of 30 years of clinical experience.
Main Results:
- Initial workup includes asthma risk factors and symptom assessment.
- Consider gastroesophageal reflux, protracted bacterial bronchitis, tracheobronchomalacia, and cystic fibrosis if asthma treatment fails.
- Perform appropriate diagnostic testing for these conditions.
Conclusions:
- In young children with recurrent lower airway symptoms and a negative modified Asthma Predictive Index, consider these alternative diagnoses.
- A systematic diagnostic approach is crucial for effective management.
Objective:
To define the diagnostic possibilities for young children who present with recurrent wheeze.
Data Sources:
Review of medical literature and 30 years of practice experience.
Study Selection:
Relevant medical literature.
Results:
When evaluating an infant or child presenting with recurrent respiratory symptoms, several diagnoses must be considered. The workup should include assessment of the risk factors for asthma and careful investigation into the specific symptoms. Recurrent or persistent wheezing and/or coughing often result in a diagnosis of asthma with therapeutic trials of asthma treatment. When the therapy is ineffective, other diagnoses should be considered, including gastroesophageal reflux, protracted bacterial bronchitis, tracheobronchomalacia, and cystic fibrosis. Appropriate testing should be performed in these pediatric patients.
Conclusion:
In young children with recurrent lower airway symptoms who have a negative modified Asthma Predictive Index result, the described diagnostic possibilities should be considered.
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