Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood-Based Biomarkers Predict Differential Longitudinal Decline in Alzheimer's Disease Psychosis: Evidence from Two Cohorts.

medRxiv : the preprint server for health sciences·2026
Same author

An isolated lateral extra-articular procedure for persisting rotatory instability following ACL reconstruction has low failure rates with good clinical and patient-reported outcomes: A systematic review and meta-analysis.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Ectopic FGFR1 Increases Intracellular Pool of Cholesterol in Prostate Cancer Cells.

International journal of molecular sciences·2026
Same author

Legacy mercury emissions and releases from colonial-era gold mining in Australia.

Environmental pollution (Barking, Essex : 1987)·2025
Same author

Peptide-based ligand antagonists block a Vibrio cholerae adhesin.

FEBS letters·2025
Same author

Multi-centre evaluation of Gram stain in the diagnosis of septic arthritis.

Journal of bone and joint infection·2025
Same journal

High-Flow Nasal Oxygen in Early Home Pulmonary Rehabilitation for Exertional Hypoxaemia: A Pilot Randomised Feasibility Trial.

Respirology (Carlton, Vic.)·2026
Same journal

Contemporary Concise Review 2025: Asthma.

Respirology (Carlton, Vic.)·2026
Same journal

Early Intervention With Biologics for Asthma Remission: Promising or Premature?

Respirology (Carlton, Vic.)·2026
Same journal

Clinical and Inflammatory Phenotypes During Exacerbations Predict In-Hospital Adverse Outcomes in Asthma-COPD Overlap.

Respirology (Carlton, Vic.)·2026
Same journal

Diagnostic Yield of EBUS Mediastinal Cryobiopsy Versus TBNA in Suspected Lymphoproliferative Disorders: A Prospective Multicentre Study.

Respirology (Carlton, Vic.)·2026
Same journal

Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre-COPD.

Respirology (Carlton, Vic.)·2026
See all related articles

Related Experiment Videos

Tuberculosis, bronchiectasis and chronic airflow obstruction.

Toni S Jordan1, Elspeth M Spencer, Peter Davies

  • 1TB Unit, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, UK. t.jordan@nhs.net

Respirology (Carlton, Vic.)
|April 23, 2010
PubMed
Summary
This summary is machine-generated.

Tuberculosis and bronchiectasis significantly impact global health, causing morbidity and mortality. Understanding their link to chronic airflow obstruction is crucial for public health.

Related Experiment Videos

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Epidemiology

Background:

  • Tuberculosis (TB) and bronchiectasis are significant global health concerns, causing substantial morbidity, mortality, and financial strain, particularly in developing nations.
  • While TB epidemiology is increasingly documented, the global prevalence of bronchiectasis, a known consequence of TB, remains largely unknown.
  • The underlying pathophysiology of chronic airflow obstruction in both TB and bronchiectasis is not well understood, yet it is linked to rapid pulmonary function decline.

Purpose of the Study:

  • To examine the global burden of tuberculosis and bronchiectasis.
  • To investigate the interrelationship between tuberculosis, bronchiectasis, and chronic airflow obstruction.

Main Methods:

  • Review of global epidemiological data for tuberculosis.
  • Analysis of the known and estimated prevalence of bronchiectasis.
  • Examination of the pathophysiology linking these conditions to chronic airflow obstruction.

Main Results:

  • Tuberculosis poses a significant and well-documented global health burden.
  • Bronchiectasis, a sequela of tuberculosis, has an unknown but considerable global prevalence.
  • Both conditions are associated with accelerated loss of pulmonary function due to poorly understood chronic airflow obstruction.

Conclusions:

  • Further research is needed to elucidate the pathophysiology of chronic airflow obstruction in tuberculosis and bronchiectasis.
  • Understanding the global burden and interrelation of these diseases is critical for public health strategies.
  • Addressing the financial and health impacts requires better data on bronchiectasis prevalence and the mechanisms of airflow obstruction.