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Related Concept Videos

Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes.
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Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

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The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
Cycloaddition Reactions: Overview01:16

Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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The Diels–Alder reaction brings together a diene and a dienophile to form a six-membered ring. Both components have unique characteristics that influence the rate of the reaction.
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.

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Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
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Published on: November 9, 2019

Current strategies for diversity-oriented synthesis.

Sivaraman Dandapani1, Lisa A Marcaurelle

  • 1Chemical Biology Platform, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

Current Opinion in Chemical Biology
|April 23, 2010
PubMed
Summary
This summary is machine-generated.

Diversity-oriented synthesis (DOS) offers novel compounds for targeting previously undruggable targets. New DOS methods enhance structural diversity, accelerating drug discovery and the development of biological probes.

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Last Updated: Jun 13, 2026

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Area of Science:

  • Medicinal Chemistry
  • Organic Synthesis
  • Drug Discovery

Background:

  • Diversity-Oriented Synthesis (DOS) is a powerful strategy for generating molecular complexity.
  • Many biological targets remain undruggable with conventional small molecules.
  • DOS approaches are crucial for exploring novel chemical space.

Purpose of the Study:

  • To highlight the recent advancements in DOS methodologies.
  • To showcase the potential of DOS-derived compounds in modulating challenging biological targets.
  • To emphasize the application of DOS in drug discovery and biological probe development.

Main Methods:

  • Development of new DOS pathways utilizing multi-component reactions, cycloadditions, and ring-closing metathesis.
  • Application of functional group pairing and 'build/couple/pair' strategies for structural diversification.
  • Construction of DOS libraries centered around privileged scaffolds.

Main Results:

  • Novel DOS pathways have been successfully developed, enabling access to diverse chemical structures.
  • DOS compounds demonstrate significant promise in modulating the activity of undruggable targets.
  • Compelling examples illustrate the utility of DOS in creating novel biological probes.

Conclusions:

  • DOS is a highly effective strategy for generating structurally diverse compounds.
  • DOS-derived molecules hold great potential for addressing challenging therapeutic targets.
  • The application of DOS in drug discovery is exceptionally promising for future therapeutic innovations.