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Updated: Feb 15, 2026

Electrophysiological Recordings of Single-cell Ion Currents Under Well-defined Shear Stress
Published on: August 2, 2019
Ion channels at the nucleus: electrophysiology meets the genome
Antonius J M Matzke1, Thomas M Weiger, Marjori Matzke
1Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria. antonius.matzke@gmi.oeaw.ac.at
Abstract:
The nuclear envelope is increasingly viewed from an electrophysiological perspective by researchers interested in signal transduction pathways that influence gene transcription and other processes in the nucleus. Here, we describe evidence for ion channels and transporters in the nuclear membranes and for possible ion gating by the nuclear pores. We argue that a systems-level understanding of cellular regulation is likely to require the assimilation of nuclear electrophysiology into molecular and biochemical signaling pathways.
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