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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Total Internal Reflection Fluorescence Microscopy01:05

Total Internal Reflection Fluorescence Microscopy

Total internal reflection fluorescence microscopy or TIRF is an advanced microscopic technique used to visualize fluorophores in samples close to a solid surface with a higher refractive index, such as a glass coverslip. TIRF only allows fluorophores in proximity to the solid surface to be excited. When light from a medium with a lower refractive index (such as air) hits the glass coverslip at a critical angle, the light undergoes total internal reflection stead of passing through the glass.
Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...

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Related Experiment Video

Updated: Jun 13, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

[Optical coherence tomography].

J Welzel1

  • 1Klinik für Dermatologie und Allergologie, Klinikum Augsburg Süd, Sauerbruchstr. 6, 86179, Augsburg, Deutschland. julia.welzel@klinikum-augsburg.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|April 23, 2010
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) provides high-resolution, non-invasive skin imaging. This technology allows objective assessment of therapeutic effects and monitoring of skin changes over time.

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Last Updated: Jun 13, 2026

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Biophotonics

Context:

  • Optical coherence tomography (OCT) is an advanced imaging technique for non-invasive in vivo examination of human skin.
  • It offers high-resolution, cross-sectional views of the skin's upper layers, reaching into the dermis.
  • While not resolving cellular details, OCT provides valuable microstructural information.

Purpose:

  • To evaluate the diagnostic significance of OCT in dermatology.
  • To explore OCT's capability in objectively assessing therapeutic effects on skin.
  • To demonstrate OCT's utility in monitoring dynamic skin changes over time.

Summary:

  • OCT enables non-invasive, high-resolution imaging of human skin architecture.
  • It allows for the assessment and long-term monitoring of skin layers and changes.
  • Current OCT configurations are suitable for evaluating treatment outcomes and observing skin evolution.

Impact:

  • OCT serves as a valuable tool for objective dermatological diagnostics.
  • It facilitates the non-invasive monitoring of skin conditions and treatment responses.
  • This imaging modality enhances the understanding and management of skin diseases.