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Related Experiment Video

Updated: Jun 13, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Statins and cognitive functioning in the elderly: a population-based study.

Juliín Benito-León¹, Elan D Louis, Saturio Vega

¹The Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain. jbenitol@meditex.es

Journal of Alzheimer'S Disease : JAD

|April 24, 2010

Summary

This summary is machine-generated.

Statins do not improve cognitive function in elderly individuals. This study found no difference in memory or thinking skills between elderly statin users and non-users.

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Area of Science:

Gerontology
Neuroscience
Pharmacology

Background:

Previous research on statins and cognitive function has yielded conflicting results.
A 2009 Cochrane review found no evidence that statins prevent Alzheimer's disease or dementia.
The impact of statins on cognitive function in the elderly remains unclear.

Purpose of the Study:

To evaluate the effect of statin treatment on cognitive function in community-dwelling elderly individuals.
To compare neuropsychological assessment results between elderly statin users and matched controls.

Main Methods:

A population-based study in central Spain (Neurological Disorders in Central Spain [NEDICES] study).
137 elderly participants receiving statins were compared with 411 matched controls (age ≥65 years).
Neuropsychological assessments included global cognition, frontal-executive function, verbal fluency, and memory tests.

Main Results:

After adjusting for multiple confounding factors, no significant differences in cognitive performance were observed between statin users and controls.
Both groups performed similarly across all tested cognitive domains.
Specific statin types included pravastatin, simvastatin, lovastatin, fluvastatin, and atorvastatin.

Conclusions:

Statin treatment in the elderly population studied did not demonstrate a positive effect on cognitive function.
These findings do not support the use of statins for cognitive enhancement in older adults.
Further research may be needed to fully elucidate the complex relationship between statins and cognition.