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Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor.

Daniella Iglesias-Hernandez¹, Silvia Chapman^2,3, Keith Radler¹

¹Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, US.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)

|May 24, 2021

Summary

Infection exposure did not impact baseline cognition in essential tremor (ET) patients. Moderate infections correlated with better attention over time, while rubella history predicted faster visuospatial decline.

Keywords:

clinical epidemiology essential tremor infection burden risk factors self-reported questionnaires

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Published on: January 24, 2020

Area of Science:

Neurology
Infectious Disease Epidemiology
Cognitive Science

Background:

Essential tremor (ET) patients face higher risks of cognitive impairment.
Infectious agent exposure is a potential, yet unexamined, predictor of cognitive decline in ET.
Previous research links infection burden to cognitive performance in Alzheimer's and Parkinson's disease.

Purpose of the Study:

To investigate the association between baseline infection burden and cognitive performance in ET patients.
To determine if infection burden predicts cognitive decline over time in essential tremor.

Main Methods:

160 non-demented elderly ET participants completed cognitive evaluations at three time points.
A validated infection burden questionnaire (t-IBQ) assessed past infectious agent exposures and episode frequency.
Statistical analyses included analysis of covariance and generalized estimating equations (GEEs).

Main Results:

No significant association was found between overall infection burden and baseline cognitive performance.
A significant time interaction indicated that moderate infection burden at baseline was linked to improved attention performance over time (p=0.013).
A history of rubella infection was associated with a faster decline in visuospatial performance (p=0.046).

Conclusions:

Findings on infection burden and cognitive performance in ET are mixed.
Moderate infection burden may be associated with better attention trajectories.
Rubella infection history appears linked to visuospatial decline in this ET cohort, warranting further investigation.