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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...

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Related Experiment Video

Updated: Jun 13, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Vascular microRNAs.

Angelika Bonauer1, Reinier A Boon, Stefanie Dimmeler

  • 1Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt University, Theodor Stern-Kai 7, Frankfurt, Germany.

Current Drug Targets
|April 27, 2010
PubMed
Summary
This summary is machine-generated.

MicroRNAs regulate vascular cell functions, impacting processes like angiogenesis and atherosclerosis. These small non-coding RNAs show potential as therapeutic targets for vascular diseases.

Related Experiment Videos

Last Updated: Jun 13, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • MicroRNAs are small non-coding RNAs regulating gene expression post-transcriptionally.
  • They play critical roles in vascular physiology and pathology.
  • Key microRNAs like miR-126, miR-296, and miR-143/145 are involved in vascular processes.

Purpose of the Study:

  • To review the function of microRNAs in endothelial and smooth muscle cells.
  • To highlight the role of specific microRNAs in vascular processes like angiogenesis and atherosclerosis.
  • To discuss the potential of microRNAs as drug targets for vascular diseases.

Main Methods:

  • Literature review of studies on microRNAs in vascular biology.
  • Analysis of microRNA involvement in endothelial and smooth muscle cell functions.
  • Examination of microRNA regulation in angiogenesis, neointima formation, and atherosclerosis.

Main Results:

  • MicroRNAs are crucial regulators of endothelial cell function and angiogenesis (e.g., miR-126, miR-17-92, miR-296, miR-378).
  • MicroRNAs modulate smooth muscle cell phenotype, influencing neointima formation and atherosclerosis (e.g., miR-143, miR-145).
  • Specific microRNAs and their target genes are implicated in various vascular conditions.

Conclusions:

  • MicroRNAs are vital regulators in vascular health and disease.
  • Targeting microRNAs offers a promising therapeutic strategy for vascular pathologies.
  • Further research into microRNA mechanisms and drug development is warranted.