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Updated: Jun 13, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Psoriasis and cardiovascular disease.

Gino A Vena¹, Michelangelo Vestita, Nicoletta Cassano

¹2nd Dermatology Clinic, University of Bari, Policlinico, Bari, Italy. g.vena@dermatologia.uniba.it

Dermatologic Therapy

|April 27, 2010

Summary

Psoriasis is linked to increased cardiovascular risk, with severity correlating to risk. Inflammation and immune responses are key factors in this association.

Area of Science:

Dermatology and Cardiology
Immunology and Vascular Biology

Background:

Epidemiological data indicate a strong association between psoriasis and cardiovascular (CV) risk.
Psoriasis patients exhibit a higher prevalence of cardiovascular diseases, including ischemic heart disease, cerebrovascular events, and peripheral vascular disorders.

Purpose of the Study:

To explore the association between psoriasis and cardiovascular risk, considering disease severity.
To investigate the underlying mechanisms linking psoriasis to cardiovascular complications.

Main Methods:

Review of current epidemiological data and existing studies.
Analysis of correlations between psoriasis severity and cardiovascular events.
Examination of proposed pathophysiological mechanisms, including inflammation and immune dysregulation.

Related Experiment Videos

Last Updated: Jun 13, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Main Results:

A correlation exists between psoriasis severity and cardiovascular risk.
Psoriasis is associated with major adverse cardiovascular events (myocardial infarction, stroke) and subclinical vascular changes (intima-media thickness, arterial stiffness, coronary calcification).
Potential mechanisms include traditional CV risk factors, inflammation (Th1/Th17/Treg imbalance, CRP, osteopontin), hemostasis dysregulation, and shared genetic factors.

Conclusions:

Inflammation and associated cytokines play a crucial role in the link between psoriasis and cardiovascular disease.
Further research is needed to fully elucidate the complex interplay of factors contributing to cardiovascular risk in psoriasis patients.