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Hyperbaric oxygen therapy for multiple sclerosis.

Michael Bennett¹, Robert Heard

¹Conjoint Associate Professor, Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital and the University of New South Wales, Barker St., Randwick, NSW 2031, Australia. m.bennett@unsw.edu.au

CNS Neuroscience & Therapeutics

|April 27, 2010

Summary

This summary is machine-generated.

Hyperbaric Oxygen Therapy (HBO(2)T) shows no significant clinical benefit for multiple sclerosis (MS) treatment. Further trials in specific MS subgroups may be warranted, but routine use is not recommended.

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Area of Science:

Neurology
Hyperbaric Medicine
Clinical Evidence Synthesis

Background:

Multiple Sclerosis (MS) is a chronic, inflammatory, and degenerative neurological disease.
Hyperbaric Oxygen Therapy (HBO(2)T) has been proposed as a potential treatment to slow MS progression.
Existing clinical evidence for HBO(2)T in MS requires comprehensive evaluation.

Purpose of the Study:

To summarize and critically appraise the clinical evidence for HBO(2)T in treating MS.
To conduct a meta-analysis of randomized controlled trials investigating HBO(2)T for MS.

Main Methods:

Systematic literature review focusing on hyperbaric oxygenation and MS interactions.
Meta-analysis of 12 randomized trials conducted between 1983 and 1987.
Evaluation of treatment protocols, including pressure (1.75-2.5 ATA), duration (60-120 min), and course (20 treatments over 4 weeks).

Main Results:

Meta-analysis indicates no clinically significant benefit of HBO(2)T for MS.
Most trials compared HBO(2)T against placebo, not current best practices.
No clear benefit identified for the clinical course of MS.

Conclusions:

HBO(2)T is not recommended for the routine treatment of MS based on current evidence.
A potential benefit in unidentified subgroups or with modified protocols (prolonged, modest pressure) is unlikely to be significant.
Further research in selected MS subgroups with extended HBO(2)T courses is cautiously suggested but not strongly supported.