Related Experiment Video
Updated: Jun 13, 2026
07:58
In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
Published on: January 2, 2026
Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes
Sofía Ballesta1, Isabel García, Javier Sánchez-Céspedez
1Departmento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain. mudarra@us.es
Enfermedades Infecciosas Y Microbiologia Clinica
|April 27, 2010
Abstract:
The intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes was evaluated. Intracellular UB-8902 concentrations were 6-fold higher than extracellular levels. Uptake was rapid, reversible, saturable, and affected by external pH. UB-8902 showed intracellular activity against Staphylococcus aureus strains presenting mutations associated with fluoroquinolone resistance in the gyrA and/or grlA genes.
