Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Testes: Histology

Testes: Histology

A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...

Testes: Gross Anatomy

Testes: Gross Anatomy

The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AFSOS-SFRO Guidelines on Radiation-Induced Lung Injury.

Clinical lung cancer·2025

Same author

Response to "Stereotactic body radiotherapy for oligoprogressive lesions in metastatic castration-resistant prostate cancer patients - A closer inspection will improve your vision".

Clinical and translational radiation oncology·2024

Same author

Stereotactic body radiation therapy to postpone systemic therapy escalation for castration-resistant prostate cancer: A multicenter retrospective analysis.

Clinical and translational radiation oncology·2024

Same author

Systemic therapy escalation after stereotactic body radiation therapy for oligometastatic hormone-sensitive prostate cancer.

Clinical and translational radiation oncology·2023

Same author

Stereotactic body radiation therapy (SBRT) as salvage treatment for early stage lung cancer with interstitial lung disease (ILD): An observational and exploratory case series of non-asian patients.

Respiratory medicine and research·2023

Same author

Split-course hypofractionated radiotherapy for aged and frail patients with head and neck cancers. A retrospective study of 75 cases.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2020

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

[Normal tissue tolerance to external beam radiation therapy: testicles].

C Champetier¹, E Gross, Y Pointreau

¹Service de Radiothérapie, Hôpital de la Timone, 264 rue Saint-Pierre, 13005 Marseille, France. c.champetier@live.fr

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique

|April 27, 2010

Summary

Radiotherapy, particularly for pelvic tumors, can significantly irradiate testes, risking male infertility. Semen preservation before treatment is recommended for adults and post-pubertal children to mitigate this risk.

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Related Experiment Videos

Last Updated: Jun 13, 2026

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Area of Science:

Oncology
Reproductive Medicine
Radiation Oncology

Background:

Testes can receive significant radiation doses during pelvic tumor treatment in both adults and pediatric patients.
The exocrine function of the testes is particularly sensitive to radiotherapy.
Even low radiation doses pose a risk of male infertility.

Purpose of the Study:

To highlight the risk of testicular damage and infertility from radiotherapy.
To recommend strategies for fertility preservation in patients undergoing radiation therapy.
To emphasize the importance of informing patients about potential reproductive side effects.

Main Methods:

Review of existing evidence on testicular irradiation during pelvic radiotherapy.
Analysis of testicular sensitivity to radiation.
Discussion of fertility preservation options.

Main Results:

Significant testicular radiation exposure can occur during pelvic tumor treatment.
Radiotherapy poses a risk of sterility, even at low doses.
Semen cryopreservation is a viable option for fertility preservation.

Conclusions:

Semen self-preservation should be offered to adult and post-pubertal male patients before radiotherapy.
Fertility preservation in pre-pubertal boys requires careful consideration.
Minimizing testicular radiation dose while ensuring adequate tumor coverage is crucial.
Systematic patient and caregiver education on radiation-induced infertility risk is essential.