Related Experiment Video
Updated: Jun 13, 2026
05:25
Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Endothelial activation after coronary artery bypass surgery: comparison between on-pump and off-pump techniques
Michael P Vallely1, Paul G Bannon, Matthew S Bayfield
1The Baird Institute, Sydney, Australia. michael.vallely@bigpond.com
Heart, Lung & Circulation
|April 27, 2010
Summary
Off-pump coronary artery bypass (OPCAB) and on-pump coronary artery bypass grafting (CABG) surgery trigger different inflammatory responses. Post-surgery plasma uniquely affects endothelial cell activation, impacting clinical outcomes.
Area of Science:
- Cardiovascular Surgery
- Immunology
- Endothelial Biology
Background:
- Endothelial cell activation is crucial in cardiovascular health.
- The impact of off-pump coronary artery bypass (OPCAB) surgery on endothelial activation remains unclear.
- Cell adhesion molecules (CAMs) indicate endothelial activation.
Purpose of the Study:
- To compare plasma levels and endothelial cell expression of CAMs after OPCAB versus conventional on-pump CABG.
- To investigate the effects of peri-operative plasma on endothelial cells.
Main Methods:
- Collected blood samples from 10 OPCAB and 10 CABG patients pre- and post-surgery.
- Assayed plasma for E-selectin, ICAM-1, and VCAM-1.
- Exposed human umbilical vein endothelial cells (HUVECs) to patient plasma and measured CAM expression.
Main Results:
- Plasma ICAM-1 and VCAM-1 increased post-operatively in both groups.
- OPCAB plasma enhanced endothelial VCAM-1 expression.
- CABG plasma (3h post-op) reduced endothelial VCAM-1 expression.
- No significant changes in E-selectin or ICAM-1 expression were observed.
Conclusions:
- OPCAB and CABG with cardiopulmonary bypass (CPB) induce distinct inflammatory responses.
- These differences in endothelial activation may have clinical significance.
