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Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
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Identification of a cellular factor that modulates HIV-1 programmed ribosomal frameshifting

Yoshifumi Kobayashi1, Jianling Zhuang, Stuart Peltz

  • 1Department of Molecular Genetics, Microbiology and Immunology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

The Journal of Biological Chemistry
|April 27, 2010
PubMed
Summary

Eukaryotic release factor 1 (eRF1) down-regulation enhances programmed ribosomal frameshifting (PRF) in HIV-1. This discovery identifies eRF1 as a key factor in viral replication and a potential antiviral target.

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