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Change in renal function after sodium phosphate preparation for screening colonoscopy
Dong Choon Seol1, Sung Noh Hong, Jeong Hwan Kim
1Healthcare Center, Konkuk University Medical Center, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, South Korea.
World Journal of Gastroenterology
|April 27, 2010
Summary
Sodium phosphate (NaP) bowel preparation for colonoscopy does not harm kidney function in patients with normal renal health. This study found no significant changes in creatinine or GFR, indicating NaP is safe for screening procedures.
Area of Science:
- Nephrology
- Gastroenterology
- Clinical Trials
Background:
- Renal function monitoring is crucial after bowel preparation.
- Sodium phosphate (NaP) is a common agent for colonoscopy preparation.
- Long-term renal effects of NaP require investigation.
Purpose of the Study:
- To assess renal function changes 12-24 months post-NaP bowel preparation for colonoscopy.
- To compare renal outcomes between NaP, polyethylene glycol (PEG), and control groups.
- To identify risk factors for decreased glomerular filtration rate (GFR).
Main Methods:
- Retrospective analysis of 224 NaP patients, 113 PEG patients, and 672 controls.
- Comparison of serum creatinine and GFR from baseline to 12-24 months.
- Statistical analysis using two-way repeated measures ANOVA and multivariate linear regression.
Main Results:
- No significant differences in creatinine or GFR changes were observed between NaP, PEG, and control groups.
- Baseline GFR was the only significant predictor of GFR change (P < 0.001).
- Bowel preparation method was not associated with GFR change (P = 0.297).
Conclusions:
- NaP bowel preparation is not associated with renal injury in patients with normal baseline renal function.
- NaP can be safely used for screening colonoscopy.
- Routine renal function monitoring post-NaP is not indicated in this population.
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