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Updated: Jun 13, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Dibromotyrosine and histamine derivatives from the tropical marine sponge Aplysina sp
Elena A Santalova1, Vladimir A Denisenko, Valentin A Stonik
1Laboratory of Marine Natural Products Chemistry, Pacific Institute of Bioorganic Chemistry of the Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Prospect 100-let Vladivostoku, 159, Russia. santalova@www.piboc.dvo.ru
Abstract:
Two new compounds, 3-amino-7,8-dihydroimidazo-[1,5-c]-pyrimidin-5(6H)-one (1) and ethyl 3-(2-amino-1H-imidazol-4-yl)propylcarbamate (2), along with the previously known 7,8-dihydroimidazo-[1,5-c]-pyrimidin-5(6H)-one (3), aeroplysinin-1 (4), dibromoverongiaquinol (5), bisoxazolidinone derivative (6), aerophobins-1 (7) and -2 (8), purealidins J (9) and L, have been isolated from Aplysina sp. from the South China Sea. The structures were elucidated on the basis of 1H, 13C NMR, MS and IR analyses. The histamine-derived alkaloids 1-3 may be unknown bioconversion products of purealidin J (9), aerophobin-2 (8) and aerophobin-1 (7), respectively, when 7-9 are cleaved at C-8-C-9 in reactions of activated chemical defense in Aplysina sponge.
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