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1,2-Cyclic acetal-type glycerophospholipids from the arctic starfish Asterias microdiscus
Alla A Kicha1, Elena A Santalova1, Timofey V Malyarenko1,2
1G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russia.
Abstract:
Unusual 1,2-cyclic acetal-type glycero-3-phosphoethanolamines, isolated from the EtOH extract of the Arctic starfish Asterias -microdiscus (Chukchi Sea), were analysed as constituents of a RP-HPLC fraction using extensive NMR, MS techniques, and chemical transformations. Four new ethanolamine glycerophospholipids were found to differ from each other in the positions of - CH = CH - CH(OOH/OH)- moieties in linear acetal-linked C20 chains. The mixture of these compounds showed cardioprotective activity against CoCl2-induced damage of H9c2 cardiomyocytes via partial restoration of mitochondrial membrane potential.
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