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A new lignan dimer from Mallotus philippensis.

Nguyen Thi Mai¹, Nguyen Xuan Cuong, Nguyen Phuong Thao

¹Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18-Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.

Natural Product Communications

|April 28, 2010

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A novel lignan dimer, bilariciresinol, was identified in Mallotus philippensis leaves. This discovery expands the known phytochemical profile of this plant species.

Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Background:

Mallotus philippensis is a plant species with a rich history of traditional medicinal uses.
The phytochemical investigation of Mallotus species is crucial for identifying bioactive compounds.

Purpose of the Study:

To isolate and characterize new compounds from the leaves of Mallotus philippensis.
To elucidate the chemical structures of isolated natural products using advanced spectroscopic techniques.

Main Methods:

Phytochemical isolation techniques were employed to extract compounds from Mallotus philippensis leaves.
Spectroscopic methods, including 1D and 2D Nuclear Magnetic Resonance (NMR) and Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry (FTICR-MS), were used for structure elucidation.

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Main Results:

A new lignan dimer, bilariciresinol (1), was successfully isolated and identified.
Six known compounds, platanoside (2), isovitexin (3), dihydromyricetin (4), bergenin (5), 4-O-galloylbergenin (6), and pachysandiol A (7), were also isolated.

Conclusions:

The study successfully identified a new lignan dimer, bilariciresinol, from Mallotus philippensis.
The findings contribute to the understanding of the chemical constituents of Mallotus philippensis and provide a basis for further pharmacological investigations.