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Updated: Jun 13, 2026
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Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents
Published on: October 26, 2016
Drug-eluting balloon: new tool in the box
Sumeet Sharma1, Neville Kukreja, Christos Christopoulos
1East & North Herts NHS Trust, Department of Cardiology, QE II Hospital, Howlands, Welwyn Garden City, UK. sumeetsharma@nhs.net
Expert Review of Medical Devices
|April 28, 2010
Summary
Drug-eluting balloons offer a promising solution to in-stent restenosis, a significant challenge in percutaneous coronary intervention. This technology aims to overcome limitations of drug-eluting stents in coronary and peripheral revascularization.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Medicine
Background:
- Percutaneous coronary intervention (PCI) is a key treatment for coronary artery disease.
- In-stent restenosis (ISR) remains a significant complication, leading to recurrent symptoms and adverse events.
- Current treatments for ISR have limitations, necessitating novel approaches.
Purpose of the Study:
- To review the limitations of drug-eluting stents (DES) in treating ISR.
- To explore the concept and evidence for drug-eluting balloons (DEBs) as an alternative.
- To focus on paclitaxel-eluting balloons for coronary and peripheral revascularization.
Main Methods:
- Literature review of studies on PCI, ISR, DES, and DEBs.
- Analysis of clinical evidence supporting the use of DEBs.
- Focus on paclitaxel-eluting balloons in various vascular beds.
Main Results:
- DES have limitations in managing ISR effectively.
- DEBs, particularly paclitaxel-eluting balloons, show potential in addressing ISR.
- Evidence suggests efficacy in both coronary and peripheral arterial applications.
Conclusions:
- DEBs represent a viable strategy to overcome ISR challenges post-PCI.
- Paclitaxel-eluting balloons are a key development in this field.
- Further research and application in clinical practice are warranted.
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